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The common cold in adults: Treatment and prevention

INTRODUCTION

The common cold is a benign self-limited syndrome representing a group of diseases caused by members of several families of viruses. It is the most frequent acute illness in the United States and throughout the industrialized world [1]. The term "common cold" refers to a mild upper respiratory viral infection involving, to variable degrees, sneezing, nasal congestion and discharge (rhinorrhea), sore throat, cough, low grade fever, headache and malaise. It is to be distinguished from influenza, pharyngitis, acute bronchitis, acute bacterial sinusitis, allergic rhinitis, and pertussis.

The common cold is associated with an enormous economic burden both in lost productivity and in expenditures for treatment [2]. Data extrapolated from a United States telephone survey conducted between 2000 to 2001 suggest that about 500 million non-influenza viral respiratory infections occur yearly, resulting in direct costs of $17 billion and indirect costs of $22.5 billion annually [3].

The average incidence of the common cold is five to seven episodes per year in preschool children, and two to three per year by adulthood. Annual absences due to colds from school and work in the United States caused 26 and 23 million lost days, respectively [2]. Colds account for 40 percent of all time lost from jobs among employed people [1]. (See "The common cold in children".)

It is no surprise then, that considerable research dollars have been spent on ways to prevent and shorten the course of the common cold. Although extensive, published literature on treatment of the common cold suffers from methodological flaws: inconsistent definitions of disease, different measured symptom outcomes, mixing of subjective and objective findings, and variable age ranges [4]. This results in significant inconsistencies in reported findings.

Treatment and prevention for the common cold are reviewed here. The epidemiology and clinical manifestations of colds are discussed separately. (See "The common cold in adults: Diagnosis and clinical features".) Specific viruses that cause colds are discussed in more detail separately.
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